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1.
Artículo en Inglés | MEDLINE | ID: mdl-38429593

RESUMEN

Solar desalination provides a sustainable and eco-friendly solution for purifying wastewater, addressing environmental challenges associated with wastewater treatment. This study focuses on the purification of inorganic contaminants from laboratory chemical wastewater (ICWW) using a spherical solar still (SSS). To enhance the evaporation rate and overcome the impact of heavy metals on absorption efficiency, a carbonized balsa wood (CBW) solar evaporator was employed. Balsa wood pieces, carbonized at 250 °C for 15 min, were arranged in a SSS configuration. The CBW-integrated SSS demonstrated a remarkable freshwater productivity of 2.33 L/m2 for ICWW, surpassing the conventional SSS, which produced only 1.5 L/m2. The presence of heavy metal ions (Na+, Ca+, K+, and Mg2+) in ICWW significantly affected the evaporation rate, and the CBW solar evaporator exhibited an impressive removal efficiency of approximately 99%. Water quality parameters, including pH and chemical oxygen demand (COD), were investigated before and after treatment. The CBW-integrated SSS achieved an outstanding COD removal efficiency of about 99.77%, reducing the COD level from 229.51 to 0.521 mg/L. These results underscore the efficacy of the proposed solar desalination system in purifying ICWW, offering a promising approach to address environmental concerns associated with wastewater treatment.

2.
Ultrasonics ; 138: 107241, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-38232448

RESUMEN

Deep learning-based super-resolution ultrasound (DL-SRU) framework has been successful in improving spatial resolution and measuring the velocity field information of a blood flows by localizing and tracking speckle signals of red blood cells (RBCs) without using any contrast agents. However, DL-SRU can localize only a small part of the speckle signals of blood flow owing to ambiguity problems encountered in the classification of blood flow signals from ultrasound B-mode images and the building up of suitable datasets required for training artificial neural networks, as well as the structural limitations of the neural network itself. An artificial intelligence-based speckle featurization and localization (AI-SFL) framework is proposed in this study. It includes a machine learning-based algorithm for classifying blood flow signals from ultrasound B-mode images, dimensionality reduction for featurizing speckle patterns of the classified blood flow signals by approximating them with quantitative values. A novel and robust neural network (ResSU-net) is trained using the online data generation (ODG) method and the extracted speckle features. The super-resolution performance of the proposed AI-SFL and ODG method is evaluated and compared with the results of previous U-net and conventional data augmentation methods under in silico conditions. The predicted locations of RBCs by the AI-SFL and DL-SRU for speckle patterns of blood flow are applied to a PTV algorithm to measure quantitative velocity fields of the flow. Finally, the feasibility of the proposed AI-SFL framework for measuring real blood flows is verified under in vivo conditions.


Asunto(s)
Algoritmos , Inteligencia Artificial , Velocidad del Flujo Sanguíneo/fisiología , Ultrasonografía , Reología/métodos
3.
Sci Adv ; 10(2): eadh1265, 2024 Jan 12.
Artículo en Inglés | MEDLINE | ID: mdl-38198546

RESUMEN

The adaptive mechanical properties of soft and fibrous biological materials are relevant to their functionality. The emergence of the macroscopic response of these materials to external stress and intrinsic cell traction from local deformations of their structural components is not well understood. Here, we investigate the nonlinear elastic behavior of blood clots by combining microscopy, rheology, and an elastic network model that incorporates the stretching, bending, and buckling of constituent fibrin fibers. By inhibiting fibrin cross-linking in blood clots, we observe an anomalous softening regime in the macroscopic shear response as well as a reduction in platelet-induced clot contractility. Our model explains these observations from two independent macroscopic measurements in a unified manner, through a single mechanical parameter, the bending stiffness of individual fibers. Supported by experimental evidence, our mechanics-based model provides a framework for predicting and comprehending the nonlinear elastic behavior of blood clots and other active biopolymer networks in general.


Asunto(s)
Plaquetas , Trombosis , Humanos , Fibrina , Microscopía , Reología
4.
Animals (Basel) ; 14(2)2024 Jan 05.
Artículo en Inglés | MEDLINE | ID: mdl-38254354

RESUMEN

The Korean water deer (WD), a predominant wildlife species in South Korea, is listed as vulnerable by the IUCN Red List. Despite belonging to the same family, Cervidae, WD show significantly fewer adult ixodid tick infestations compared to roe deer (RD). Ticks, which cannot fly, engage in questing behavior in natural environments to latch onto hosts. They detect signals like body temperature and host skin chemicals to navigate through the hair coat to the preferred epidermis. In light of this, we performed an extensive comparative study of the skin tissue and hair characteristics of both deer species, focusing on elements contributing to the reduced tick bite incidence in WD. Remarkably, WD exhibited more prominent blood vessels, sebaceous glands, and sweat glands, which are crucial for skin barrier functions (p < 0.005). Moreover, WD had irregular scale patterns on their hair cuticles and possessed hair that was significantly stiffer and 2.83 times thicker than that of RD (p < 0.001). These characteristics potentially impede ticks from reaching the epidermis hair in WD and RD in the context of tick bite prevention. Further investigations in this area could enhance our understanding of tick-host dynamics and contribute to developing preventive measures against tick-borne diseases in other deer species.

5.
Int J Mol Sci ; 25(2)2024 Jan 08.
Artículo en Inglés | MEDLINE | ID: mdl-38255858

RESUMEN

Cirsium japonicum is a medicinal plant that has been used due to its beneficial properties. However, extensive information regarding its therapeutic potential is scarce in the scientific literature. The antioxidant and anti-inflammatory potential of polyphenols derived from the Cirsium japonicum extracts (CJE) was systematically analyzed. High-performance liquid chromatography (HPLC) with mass spectrometry (MS) was used to examine the compounds in CJE. A total of six peaks of polyphenol compounds were identified in the extract, and their MS data were also confirmed. These bioactive compounds were subjected to ultrafiltration with LC analysis to assess their potential for targeting cyclooxygenase-2 (COX2) and DPPH. The outcomes showed which primary compounds had the highest affinity for binding both COX2 and DPPH. This suggests that components that showed excellent binding ability to DPPH and COX2 can be considered significant active substances. Additionally, in vitro analysis of CJE was carried out in macrophage cells after inducing inflammation with lipopolysaccharide (LPS). As a result, it downregulated the expression of two critical pro-inflammatory cytokines, COX2 and inducible nitric oxide synthase (iNOS). In addition, we found a solid binding ability through the molecular docking analysis of the selected compounds with inflammatory mediators. In conclusion, we identified polyphenolic compounds in CJE extract and confirmed their potential antioxidant and anti-inflammatory effects. These results may provide primary data for the application of CJE in the food and pharmaceutical industries with further analysis.


Asunto(s)
Antioxidantes , Cirsium , Antioxidantes/farmacología , Ciclooxigenasa 2 , Simulación del Acoplamiento Molecular , Antiinflamatorios/farmacología , Polifenoles/farmacología , Extractos Vegetales/farmacología
6.
Environ Sci Pollut Res Int ; 30(58): 121759-121769, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37953425

RESUMEN

Solar energy is one of the sustainable sources for many fruitful applications. Desalination of wastewater by solar power is a priority research focus and has attracted many researchers and scientists world-wide. However, handling industrial and other wastewater is typically a challenging task for effective treatment and re-use. The presence of contaminants in the effluent is hazardous to the environment and human health. In the present work, an attempt has been made to investigate different wastewaters including (i) garbage wastewater, (ii) waste vegetable water, (iii) landfill leachate, and (iv) pharmaceutical effluent fed into a solar distiller evaporated under natural solar illumination. Herein, different waste waters' pH, chemical oxygen demand (COD), ammoniacal-nitrogen (NH3-N), arsenic (As), Barium (Ba), Cobalt (CO), Chromium (Cr), Iron (Fe), Mercury (Hg), Potassium (K), Manganese (Mn), Magnesium (Mg), Sodium (Na), Nickel (Ni), Phosphate (P), and Zinc (Zn) were investigated by the inductively coupled plasma-atomic emission spectroscopy (ICP-AES). The concentration of NH3-N in the garbage wastewater, vegetables wastewater, landfill leachate, and pharmaceutical effluent were 157 mg/L, 142 mg/L, 161 mg/L, and 164 mg/L, respectively. The evaporated water output of garbage, waste-vegetable water, landfill leachate, and pharmaceutical effluents are 1.7 L/m2.day, 1.8 L/m2.day, 1.9 L/m2.day, and 1.65 L/m2.day, respectively. Finally, the test result reveals that the water quality is greatly improved after consecutive evaporation process by the solar distiller. This is one way to deal with the wastewater through a sustainable process for a better future.


Asunto(s)
Aguas Residuales , Contaminantes Químicos del Agua , Humanos , Hierro , Preparaciones Farmacéuticas , Luz Solar , Contaminantes Químicos del Agua/análisis , Purificación del Agua
7.
ACS Appl Energy Mater ; 6(18): 9400-9408, 2023 Sep 25.
Artículo en Inglés | MEDLINE | ID: mdl-37779902

RESUMEN

Composite polymer electrolytes (CPEs) strike an effective balance between ionic conductivity and mechanical flexibility for lithium-ion solid-state batteries. Long-term performance, however, is limited by capacity fading after hundreds of charge and discharge cycles. The causes of performance degradation include multiple contributing factors such as dendrite formation, physicochemical changes in electrolytes, and structural remodeling of porous electrodes. Among the many factors that contribute to performance degradation, the effect of stress specifically on the composite electrolyte is not well understood. This study examines the mechanical changes in a poly(ethylene oxide) electrolyte with bis(trifluoromethane) sulfonimide. Two different sizes of Li6.4La3Zr1.4Ta0.6O12 particles (500 nm and 5 µm) are compared to evaluate the effect of the surface-to-volume ratio of the ion-conducting fillers within the composite. Cyclic compression was applied to mimic stress cycling in the electrolyte, which would be caused by asymmetric volume changes that occur during charging and discharging cycles. The electrolytes exhibited fatigue softening, whereby the compressive modulus gradually decreased with an increase in the number of cycles. When the electrolyte was tested for 500 cycles at 30% compressive strain, the compressive modulus of the electrolyte was reduced to approximately 80% of the modulus before cycling. While the extent of softening was similar regardless of particle size, CPEs with 500 nm particles exhibited a significant reduction in ionic conductivity after cyclic compression (1.4 × 10-7 ± 2.3 × 10-8 vs 1.1 × 10-7 ± 2.0 × 10-8 S/cm, mean ± standard deviation, n = 4), whereas there was no significant change in ionic conductivity for CPEs with 5 µm particles. These observations -performed deliberately in the absence of charge-discharge cycles -show that repetitive mechanical stresses can play a significant role in altering the performance of CPEs, thereby revealing another possible mechanism for performance degradation in all-solid-state batteries.

8.
Cell Rep ; 42(9): 113054, 2023 09 26.
Artículo en Inglés | MEDLINE | ID: mdl-37656622

RESUMEN

Most mutations in retinitis pigmentosa (RP) arise in rod photoreceptors, but cone photoreceptors, responsible for high-resolution daylight and color vision, are subsequently affected, causing the most debilitating features of the disease. We used mass spectroscopy to follow 13C metabolites delivered to the outer retina and single-cell RNA sequencing to assess photoreceptor transcriptomes. The S cone metabolic transcriptome suggests engagement of the TCA cycle and ongoing response to ROS characteristic of oxidative phosphorylation, which we link to their histone modification transcriptome. Tumor necrosis factor (TNF) and its downstream effector RIP3, which drive ROS generation via mitochondrial dysfunction, are induced and activated as S cones undergo early apoptosis in RP. The long/medium-wavelength (L/M) cone transcriptome shows enhanced glycolytic capacity, which maintains their function as RP progresses. Then, as extracellular glucose eventually diminishes, L/M cones are sustained in long-term dormancy by lactate metabolism.


Asunto(s)
Células Fotorreceptoras Retinianas Conos , Retinitis Pigmentosa , Humanos , Células Fotorreceptoras Retinianas Conos/metabolismo , Transcriptoma/genética , Especies Reactivas de Oxígeno/metabolismo , Retina/metabolismo , Retinitis Pigmentosa/patología
9.
PLoS One ; 18(7): e0287560, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37418390

RESUMEN

Methods for obtaining valuable knowledge from the vast amount of mixed-quality information have become a top priority for knowledge demanders. As an online knowledge-sharing channel, the socialized question and answer (Q&A) platform provides important support services for knowledge payment. Based on the personal psychological dimensions of users and social capital theory, this paper aims to study the behavior mechanisms of knowledge payment users and examine the significant factors affecting user payment. Our research was conducted in two steps: a qualitative study to find these factors and a research model based on a quantitative study for testing the hypothesis. The results show that the three dimensions of individual psychology are not all positively correlated with cognitive and structural capital. Our results fill a gap in the literature on the formation of social capital in the knowledge payment environment by showing how individual psychological dimensions affect cognitive and structural capital differently. Thus, this study offers effective countermeasures for knowledge producers on social Q&A platforms to better amass their social capital. This research also makes practical recommendations for social Q&A platforms to strengthen the knowledge payment model.


Asunto(s)
Conducta Social , Capital Social , Investigación Cualitativa
10.
Animals (Basel) ; 13(13)2023 Jun 29.
Artículo en Inglés | MEDLINE | ID: mdl-37443947

RESUMEN

Korean native cattle are highly valued for their rich marbling and flavor. Nonetheless, endeavors to enhance marbling levels can result in obesity, a prevalent contributor to fat necrosis. Fat necrosis is characterized by the formation of necrotic fat masses in the abdominal cavity, which physically puts pressure on affected organs, causing physical torsion or obstruction, resulting in death and consequent economic loss. Pancreatic injuries or diabetes mellitus were reported as factors of fat necrosis in humans; however, the pathogenesis in animals has not been established. In this study, we identified fat necrosis in a 6-month-old Korean native cow and investigated its potential underlying causes. Serum samples were utilized for a microarray analysis of bovine miRNA. Comparative examination of miRNA expression levels between cattle afflicted with fat necrosis and healthy cattle unveiled notable variances in 24 miRNAs, such as bta-miR-26a, bta-miR-29a, bta-miR-30a-5p and bta-miR-181a. Upon conducting miRNA-mediated KEGG pathway analysis, several pathways including the prolactin signal pathway, insulin resistance, autophagy, the insulin-signaling pathway and the FoxO-signaling pathway were found to be significantly enriched in the calf affected by fat necrosis. As a result, this study potentially indicates a potential connection between fat necrosis and diabetes in Korean native cattle.

11.
Vaccines (Basel) ; 11(5)2023 May 09.
Artículo en Inglés | MEDLINE | ID: mdl-37243069

RESUMEN

Newborn piglets are susceptible to a highly contagious enteritis caused by the porcine epidemic diarrhea virus (PEDV), associated with high levels of mortality worldwide. There is pressing need for a rapid, safe, and cost-effective vaccine to safeguard pigs from getting infected by PEDV. PEDV belongs to the coronavirus family and is characterized by high levels of mutability. The primary goal of a PEDV vaccine is to provide immunity to newborn piglets through vaccination of sows. Plant-based vaccines are becoming more popular because they have low manufacturing costs, are easily scalable, have high thermostability, and a long shelf life. This is in contrast to conventional vaccines which include inactivated, live, and/or recombinant types that can be expensive and have limited ability to respond to rapidly mutating viruses. The binding of the virus to host cell receptors is primarily facilitated by the N-terminal subunit of the viral spike protein (S1), which also contains several epitopes that are recognized by virus-neutralizing antibodies. As a result, we generated a recombinant S1 protein using a plant-based vaccine platform. We found that the recombinant protein was highly glycosylated, comparable to the native viral antigen. Vaccination of pregnant sows at four and two weeks before farrowing led to the development of humoral immunity specific to S1 in the suckling piglets. In addition, we noted significant viral neutralization titers in both vaccinated sows and piglets. When challenged with PEDV, piglets born from vaccinated sows displayed less severe clinical symptoms and significantly lower mortality rates compared to piglets born from non-vaccinated sows.

12.
Environ Sci Pollut Res Int ; 30(25): 67686-67698, 2023 May.
Artículo en Inglés | MEDLINE | ID: mdl-37115438

RESUMEN

Although solar desalination is a promising approach for obtaining freshwater, its practical application encounters challenges in achieving efficient photothermal evaporation. Recent research has focused on novel configurations of solar absorbers with unique structural features that can minimize heat loss. High-efficiency interfacial solar steam generation (SSG) can be achieved by optimizing the design of the absorber to harness incident heat energy on the top interfacial surface and ensuring a continuous water supply through microchannels. Artificially nanostructured absorbers might have high solar absorptivity and thermal stability. However, the manufacturing of absorbers is expensive, and the constituting materials are typically non-biodegradable. The unique structural configuration of natural plant-based solar absorbers provides a major breakthrough in SSG. Bamboo, as a natural biomass, possesses exceptional mechanical strength and excellent water transport through vertically oriented microchannels. This study aimed to enhance the performance of SSG with a carbonized bamboo-based solar absorber (CBSA). To achieve this goal, we optimized the carbonization thickness of the absorber by varying the carbonization time. Furthermore, the height of the CBSA was varied from 5 to 45 mm to determine the optimal height for effective solar evaporation. Accordingly, the highest evaporation rate of 3.09 kg m-2 h-1 was achieved for the CBSA height of 10 mm and top-layer carbonization thickness of 5 mm. The cost-effectiveness, simple fabrication, and superior desalination performance of the CBSA demonstrate a strong potential for practical applications.


Asunto(s)
Purificación del Agua , Abastecimiento de Agua , Transporte Biológico , Biomasa , Comercio , Vapor
13.
BioDrugs ; 37(3): 433-440, 2023 May.
Artículo en Inglés | MEDLINE | ID: mdl-36881323

RESUMEN

BACKGROUND: The Phase 3 CT-P6 3.2 study demonstrated equivalent efficacy and comparable safety between CT-P6 and reference trastuzumab in patients with human epidermal growth factor receptor-2 (HER2)-positive early breast cancer after up to 3 years' follow-up. OBJECTIVE: To investigate long-term survival with CT-P6 and reference trastuzumab. METHODS: In the CT-P6 3.2 study, patients with HER2-positive early breast cancer were randomised to neoadjuvant chemotherapy with CT-P6 or reference trastuzumab, surgery, and adjuvant CT-P6 or reference trastuzumab before a 3-year post-treatment follow-up. Patients who completed the study could enter a 3-year extension (CT-P6 4.2 study). Data were collected every 6 months to assess overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS). RESULTS: Of 549 patients enrolled in the CT-P6 3.2 study, 216 (39.3%) patients continued in the CT-P6 4.2 study (CT-P6, 107; reference trastuzumab, 109) (intention-to-treat extension set). Median follow-up was 76.4 months for both groups. Medians were not reached for time-to-event parameters; estimated hazard ratios (95% confidence intervals) for CT-P6 versus reference trastuzumab were 0.59 (0.17-2.02) for OS, 1.07 (0.50-2.32) for DFS, and 1.08 (0.50-2.34) for PFS. Corresponding 6-year survival rates in the CT-P6 and reference trastuzumab groups, respectively, were 0.96 (0.90-0.99) and 0.94 (0.87-0.97), 0.87 (0.78-0.92) and 0.89 (0.81-0.94), and 0.87 (0.78-0.92) and 0.89 (0.82-0.94). CONCLUSIONS: Data from this extended follow-up of the CT-P6 3.2 study demonstrate the comparable long-term efficacy of CT-P6 and reference trastuzumab up to 6 years. EUDRACT NUMBER: 2019-003518-15 (retrospectively registered 10 March 2020).


Asunto(s)
Biosimilares Farmacéuticos , Neoplasias de la Mama , Humanos , Femenino , Neoplasias de la Mama/tratamiento farmacológico , Neoplasias de la Mama/metabolismo , Estudios de Seguimiento , Trastuzumab , Receptor ErbB-2/metabolismo , Biosimilares Farmacéuticos/uso terapéutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico
14.
Biosens Bioelectron ; 229: 115232, 2023 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-36963327

RESUMEN

The morphological and mechanical characteristics of red blood cells (RBCs) largely vary depending on the occurrence of hematologic disorders. Variations in the rheological properties of RBCs affect the dynamic motions of RBCs, especially their rotational behavior. However, conventional techniques for measuring the orientation of biconcave-shaped RBCs still have some technical limitations, including complicated optical setups, complex post data processing, and low throughput. In this study, we propose a novel image-based technique for measuring 3D position and orientation of normal RBCs using digital in-line holographic microscopy (DIHM) and artificial intelligence (AI). Formaldehyde-fixed RBCs are immobilized in coagulated polydimethylsiloxane (PDMS). Holographic images of RBCs positioned at various out-of-plane angles are acquired by precisely manipulating the PDMS-trapped RBC sample attached to a 4-axis optical stage. With the aid of deep learning algorithms for data augmentation and regression analysis, the out-of-plane angle of RBCs is directly predicted from the captured holographic images. The 3D position and in-plane angle of RBCs are acquired by employing numerical reconstruction and ellipse detection methods. Combining these digital image processing techniques, the 3D positional and orientational information of each RBC recorded in a single holographic image is measured within 23.5 and 3.07 s, respectively. The proposed AI-based DIHM technique that can extract the 3D position, orientation, and morphology of individual RBCs would be utilized to analyze the dynamic translational and rotational motions of abnormal RBCs with hematologic disorders in shear flows through further research.


Asunto(s)
Técnicas Biosensibles , Holografía , Microscopía/métodos , Inteligencia Artificial , Holografía/métodos , Eritrocitos
15.
Artículo en Inglés | MEDLINE | ID: mdl-36763034

RESUMEN

Recently, intercalation pseudocapacitance has received significant interest as an abnormal charge storage mechanism owing to the battery-like intercalation energy storage into the bulk electrodes and the fast charge storage kinetics of electrochemical capacitors. However, intercalation pseudocapacitance of molybdenum-based polyoxometalates (POMs) for high-performance Zn ion battery (ZIB) cathodes is yet to be exploited. Herein, we demonstrate the fast and reversible intercalation pseudocapacitance of vanadium-substituted Keggin-type molybdenum-based POMs (XPMoV), where H of HPMoV is replaced by X cations (X = Li, Na, K, or Rb). This cation exchange allows cation-exchanged XPMoV to exhibit the morphological evolution into an anisotropic rodlike structure and to achieve a pillar effect on the improved chemical and structural integrity. Despite the micron-size rod morphology and the contracted lattice of (100) plane, the intercalation pseudocapacitance kinetics of XPMoV was dominated by the fast surface-confined electrochemistry and became highly reversible after the 1st cycle activation process by co-intercalation of Li+ and Zn2+ ions. Therefore, the ZIB with the KPMoV cathode delivered a high rate capability of 74.0 mAh g-1 at 20,000 mA g-1 and 87% capacity retention over 2000 cycles at 1000 mA g-1, far exceeding HPMoV and other Mo-based cathodes. This study paves the way to design the fast and reversible intercalation pseudocapacitance of POMs and the cation exchange chemistry into the improved (electro)chemical and structural integrity.

16.
ACS Omega ; 8(2): 2740-2751, 2023 Jan 17.
Artículo en Inglés | MEDLINE | ID: mdl-36687106

RESUMEN

Diesel particulate matter (DPM) generated as vehicular exhaust is one of the main sources of atmospheric soot. These soot particles have been known to cause adverse health problems in humans and cause acute environmental problems. Despite great efforts for minimizing soot production, research on the disposal and recycling of inevitable diesel soot is scarce. However, DPM consists mainly of carbonaceous soot (DS) that can be easily utilized as a photothermal material for solar desalination. Recently, interfacial solar steam generation using three-dimensional (3D) structures has gained extensive attention. 3D-structured hydrogels have exhibited incredible performance in solar desalination owing to their tunable physicochemical properties, hydrophilicity, intrinsic heat localization, and excellent water transport capability. Herein, a novel DS-incorporated 3D polyvinyl alcohol (PVA)-based hydrogel is proposed for highly efficient solar desalination. The polymer network incorporated with purified DS (DSH) achieved an excellent evaporation rate of 3.01 kg m-2 h-1 under 1 sun illumination due to its vertically aligned water channels, hydrophilicity, and intrinsic porous structure. In addition, the DSH-PVA hydrogel could generate desalinated water efficiently (2.5 kg m-2 h-1) with anti-salt fouling properties. The present results would motivate the utilization and recycling of waste materials like DS as photothermal materials for efficient, low-cost, and sustainable solar desalination.

17.
JAMA Ophthalmol ; 141(3): 226-233, 2023 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-36656597

RESUMEN

Importance: Fungal endophthalmitis caused by contaminated medical products is extremely rare; it follows an intractable clinical course with a poor visual prognosis. Objective: To report the epidemiologic and clinical features and treatment outcomes of a nationwide fungal endophthalmitis outbreak after cataract surgery as a result of contaminated viscoelastic agents in South Korea. Design, Setting, and Participants: This was a retrospective case series analysis of clinical data from multiple institutions in South Korea conducted from September 1, 2020, to October 31, 2021. Data were collected through nationwide surveys in May and October 2021 from the 100 members of the Korean Retinal Society. Patients were diagnosed with fungal endophthalmitis resulting from the use of the viscoelastic material sodium hyaluronate (Unial [Unimed Pharmaceutical Inc]). Data were analyzed from November 1, 2021, to May 30, 2022. Main Outcomes and Measures: The clinical features and causative species were identified, and treatment outcomes were analyzed for patients who underwent 6 months of follow-up. Results: The fungal endophthalmitis outbreak developed between September 1, 2020, and June 30, 2021, and peaked in November 2020. An official investigation by the Korea Disease Control and Prevention Agency confirmed contamination of viscoelastic material. All 281 eyes of 265 patients (mean [SD] age, 65.4 [10.8] years; 153 female individuals [57.7%]) were diagnosed with fungal endophthalmitis, based on clinical examinations and supportive culture results. The mean (SD) time period between cataract surgery and diagnosis was 24.7 (17.3) days. Patients exhibited characteristic clinical features of fungal endophthalmitis, including vitreous opacity (212 of 281 [75.4%]), infiltration into the intraocular lens (143 of 281 [50.9%]), and ciliary infiltration (55 of 281 [19.6%]). Cultures were performed in 260 eyes, and fungal presence was confirmed in 103 eyes (39.6%). Among them, Fusarium species were identified in 89 eyes (86.4%). Among the 228 eyes included in the treatment outcome analysis, the mean (SD) best-corrected visual acuity improved from 0.78 (0.74) logMAR (Snellen equivalent, 20/120 [7.3 lines]) to 0.36 (0.49) logMAR (Snellen equivalent, 20/45 [4.9 lines]) at 6 months. Furthermore, disease remission with no signs of fungal endophthalmitis (or cells in the anterior chamber milder than grade 1) was noted in 214 eyes (93.9%). Conclusions and Relevance: This was a retrospectively reviewed case series of a fungal endophthalmitis outbreak resulting from contaminated viscoelastic material. Findings of this case series study support the potential benefit of prompt, aggressive surgical intervention that may reduce treatment burden and improve prognosis of fungal endophthalmitis caused by contaminated medical products.


Asunto(s)
Extracción de Catarata , Catarata , Endoftalmitis , Infecciones Bacterianas del Ojo , Infecciones Fúngicas del Ojo , Humanos , Femenino , Anciano , Estudios Retrospectivos , Vitrectomía/efectos adversos , Endoftalmitis/diagnóstico , Endoftalmitis/tratamiento farmacológico , Endoftalmitis/epidemiología , Infecciones Fúngicas del Ojo/diagnóstico , Infecciones Fúngicas del Ojo/tratamiento farmacológico , Infecciones Fúngicas del Ojo/epidemiología , Extracción de Catarata/efectos adversos , Brotes de Enfermedades , Catarata/epidemiología , Antibacterianos/uso terapéutico , Infecciones Bacterianas del Ojo/diagnóstico
18.
J Environ Manage ; 332: 117313, 2023 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-36716541

RESUMEN

Phytoremediation has emerged as an ecofriendly technique to reduce hazardous particulate matter (PM) in the air. Although previous studies have conducted statistical analyses to reveal PM removal capabilities of various plant species according to their leaf characteristics, the underlying physical mechanism of PM adsorption of plants remains unclear. Conventional methodologies for measuring PM accumulation usually require long-term field tests and provide limited understanding on PM removal effects of individual leaf traits of various plants. In this study, we propose a novel methodology which can compare the electrostatic interactions between PMs and plant leaves according to their trichome structures by using digital in-line holographic microscopy (DIHM). Surface characteristics of Perilla frutescens and Capsicum annuum leaves are measured to examine electrostatic effects according to the morphological features of trichomes. 3D settling motions of PMs near the microstructures of trichomes of the two plant species are compared in detail. To validate the PM removal effect of the hairy microstructures, a polydimethylsiloxane (PDMS) replica model of a P. frutescens leaf is fabricated to demonstrate accelerated settling velocities of PMs near trichome-like microstructures. The size and electric charge distributions of PMs with irregular shapes are analyzed using DIHM. Numerical simulation of the PM deposition near a trichome-like structure is conducted to verify the empirical results. As a result, the settling velocities of PMs on P. frutescens leaves and a PDMS replica sample are 12.11 ± 1.88% and 34.06 ± 4.19% faster than those on C. annuum leaves and a flat PDMS sample, respectively. These findings indicate that the curved microstructures of hairy trichomes of plant leaves increase the ability to capture PMs by enhancing the electric field intensity just near trichomes. Compared with conventional methods, the proposed methodology can quantitatively evaluate the settling velocity of PMs on various plant leaves according to the morphological structure and density of trichomes within a short period of time. The present research findings would be widely utilized in the selection of suitable air-purifying plants for sustainable removal of harmful air pollutants in urban and indoor environments.


Asunto(s)
Contaminantes Atmosféricos , Material Particulado , Material Particulado/análisis , Monitoreo del Ambiente/métodos , Contaminantes Atmosféricos/análisis , Plantas , Hojas de la Planta/química
19.
Small Methods ; 7(8): e2201440, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-36707415

RESUMEN

Recently, anion storage materials have gained significant attention owing to the widened cell voltage and additional anion storing capacity for a large energy density. MXenes are considered as the emerging anion storing materials owing to their sufficient interlayer spacing, rich surface chemistries, tunable structures, remarkable electrochemical properties, and mechanical integrity. Herein, a comprehensive review on the anion storage of MXenes covering their anion storage mechanism and state-of-the-art chemical strategies for the improved anion storage performances is reported. The recent progress of MXenes on aluminum ion batteries, metal halogen batteries, halogen ion batteries, and electrochemical electrode deionization is addressed. The scientific and technical challenges and the research direction into the anion storage of MXenes are also addressed and finally the authors' perspective on anion storage of MXenes is provided. Therefore, this review offers an insight into the rational design of MXenes for anion storage materials and the correlation of surface chemistries and structural modifications with anion storage properties for the applications into electrochemical energy storage and water purification.

20.
J Vis (Tokyo) ; 26(2): 289-298, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36186949

RESUMEN

The recent Coronavirus Disease 2019 pandemic has highlighted the importance of indoor ventilation. In particular, ventilation is crucial in residential spaces and workspaces, where people spent most of their day. Natural ventilation is a cost-effective method for improving indoor ventilation. It can provide safe and comfortable residential and working environments without additional energy consumption. In this study, the ventilation performance was experimentally studied by measuring the concentration of ultrafine particulate matter according to the opening conditions of the windows and door of an office model in a wind tunnel. Furthermore, the internal flow structure in the office model was quantitatively analyzed through particle image velocimetry to determine the factors that affected the ventilation performance. The mean velocity inside the model and the ventilation performance increased with the opening angle of the windows. In particular, the opening condition of the door strongly affected the ventilation performance. This study is expected to provide a guideline for effectively improving the ventilation performance in indoor spaces.

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